With three deaths already on open roads this week, the roads policing unit is issuing an urgent appeal to riders and motorists to take extra care.
They say that means travelling at the right speed for the road conditions and riding within your own ability.
Inspector Terry Stephen says the recent warm weather has probably tempted more riders than normal to go out for a lap.
And he's stressing that roads around the course can still be busy with traffic first thing in the morning.
Rapid bed review finds 'deep rooted behavioural and cultural issues' at Noble's Hospital
Advises against increasing capacity 'without root-cause improvements'
'Iconic' 250-year-old Ballaugh elm trees felled due to disease
Commissioner's Chair Steve Curphey says residents have 'fond memories' of the trees
Report published following rapid review of bed capacity at Noble’s Hospital
Nine recommendations made by independent reviewer
'Big discussions' to be had over whether Isle of Man follows UK-style social media ban
Sir Keir Starmer announces 2027 ban for apps like Snapchat and TikTok
Assisted Dying Bill: Will it get royal assent?
Amendments due to be debated in Tynwald