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Emergency services have been dealing with a road accident near the Nunnery, on the Old Castletown Road.
A car and a motorcycle were involved, but no further information is available about what happened.
The southbound carriageway has reopened in the past few minutes (6.05pm), and police say they will get the northbound lane open to traffic as soon as possible.
Motorists have been advised to take an alternative route.
Drone pilots warned of exclusion zones during road racing
Restrictions also in force during Red Arrows
No self-driving car laws expected before 2027
Minister says currently 'no risk' of autonomous vehicles being brought to the Island
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Chief minister won't be drawn on if he's standing in September
Techstars Startup event to take place in July
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Tynwald petitioners advised to seek advice
Guidance can be found online or from the Legislative Buildings