Kirk Michael and Ramsey affected
Tree felling following Storm Brendan has necessitated road closures in the north and west of the Island.
The Balleira Road in Kirk Michael will remain shut until no later than midday on Thursday.
Access for residents is being maintained.
The Department of Infrastructure says specialist equipment needs to be used because of overhead cables.
Meanwhile, Claughbane Walk in Ramsey is shut from its junction with the Crescent West the one with the Crescent East, until no later than 4.30pm on Wednesday.
Police make further appeal for witnesses to Douglas fight
'Parasite politicians are not what is needed'
Former bodyguard to late Queen to start Tai Chi classes
Minister: 'Very live' pressures facing Island families
What next for Manx Telecom after Jersey Telecom's acquisition?