Manx cyclist Jonny Bellis will be one of the first from the British team in action.
The 248 kilometre road race begins at 4 o'clock our time Saturday morning.
Former Olympic cyclist Marie Noon says the timing may mean Jonny missing today's Opening Ceremony:-
Football: Women's league title in sight for Peel
Westerners have six point lead after win over Corinthians
Manx duo heading to cheerleading world championships
They'll represent the Island in pom doubles in the USA this week
Athletics: Big Island turnout expected at Manchester Marathon
It's the second largest event of its type in the UK
Football: Colby stun defending champions in Hospital Cup
Douglas High School Old Boys relegated from premier league during Saturday clashes
Rugby: Douglas beaten in Regional 2 North West play-offs
Ramsey win final home game of their season against Congleton