Premier League leaders Old Boys and second placed Laxey have the chance to go five points clear of reigning champions St George's this afternoon (Saturday).
Geordies don't play, while Old Boys travel to Corinthians looking to make it six wins out of six.
Laxey have played a game more than the Blackberry Lane side, but can open up the same margin if they bag all three points at home to Ramsey.
There's a big clash in Division Two, with the top two sides meeting at Garey Moar.
Union Mills host Marown who lead them on goal difference, both teams having won all six games played so far.
FC Isle of Man returning to league action at Barnoldswick Town
Hockey: Compact mixed schedule on the cards this weekend
Rugby: Busy triple-header beckons at Ballafletcher
Football: Race for Railway Cup qualification hotting up