Castletown or Rushen v Pulrose
Ramsey v St George's
Ayre v Peel
St Mary's v Laxey
The draw was made live on Manx Radio on Saturday evening.
Ties to be played Saturday, March 6.
Draw for Cu-Plas FA Cup quarter-finals
More from Isle of Man Sport
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Football: IoM women looking forward to Kendal Town test
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FC Isle of Man to face Brackley Town in first pre-season friendly
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Handball: Isle of Man becomes England talent pathway
System could help local players compete internationally in future
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Athletics: David Mullarkey in GB squad for European team championships
Island athlete to contest 5,000m race in Madrid later this month
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Boxing: Sam Rennie not ruling out further title push this year
Manxman hoping to build on recent WBC title victory