Onchan surprised Ayre United in the GH Corlett Woods Cup preliminary round.
Craig Marsh, Mark Burman, Gerard Colligon and Mark Rees were on target in a 4-2 home win.
Phil Quayle and Elliot Cureton replied for the Tangerines.
Douglas Athletic are up to fifth in JCK Division Two after an 8-1 thrashing of Braddan.
A Josh Green treble, a Liam Dawson double and further goals from Darren Shields, Andy Newton and Stuart Monks (penalty) secured the three points to lift them above Colby in the table.
Tributes paid to Island resident and Olympic Silver medallist, Maurice Herriott
"A remarkable athlete, and a big part of our community."
Billy Harris beaten in US Open Qualification
Island player lost by two sets to one
'She changed my life': Tributes paid to former schoolteacher
'Mrs Messenger' was a netball coach and taught at Castle Rushen High School
David Mullarkey selected by Great Britain for road running championships
Island athletics star heading for Denmark