With Sure Mobile Premier League leaders Peel not playing, the chasing pack have the chance to make up ground.
Champions St. George's are second in the table and play Colby at home, while third placed St. Mary's visit Michael.
Rushen and Old Boys clash in the most important game with both clubs still hoping to make the Railway Cup semi-final line-up.
In Rugby, Vagabonds have a 100% winning home record, but have still to win on the road. This afternoon, they visit Wigan in South Lancashire and Cheshire Division One.
In Division Two, Douglas entertain Wallasey.
And unbeaten Vagabonds Women look to stay top of North West Division Two away at Northwich.
In Hockey, the Mixed Premier League clash between leaders Bacchas "A" and their "B" team has been postponed as Bacchas men's side is away this weekend.
They play City of Manchester tomorrow in the English Hockey Association Trophy competition.
This afternoon, fellow title-chasers Falcons and Valkyrs "A" play Ramsey "A" and Phoenix respectively.
Traditional sport set to be recognised on coin
Athletics: Manx athlete impresses in US
Football: St Mary's sink Union Mills on disrupted Saturday
Hockey: Bacchas crowned Mixed Prem Champions
FC IoM comeback secures 3-3 draw with Pilkington