FA Cup holders St Mary’s will host St George’s in a repeat of last year’s final.
In the other tie, Ramsey will meet Peel.
The semi-final draw was made live on Manx Radio on Saturday evening.
Paddy Power FA Cup semi-finals
St Mary’s v St George’s
Ramsey v Peel
Football: Ramsey and Laxey to meet in 2025 Hospital Cup final
It'll be repeat of 2024 occasion later this month
Cycling: Nine riders to represent IoM at 2025 Island Games
Manx squad to contest all road and MTB races
Marown AFC pays tribute to president and treasurer
Keir Morris described as a club 'legend'
Hockey: IoM Ladies B team bound for cup final this weekend
Manx team heading to London aiming to win EH Tier 3 Plate
Rugby: Season finale this weekend for Manx cup finals
Three matches including Manx Cup final to be held at Ballafletcher