FA Cup holders St Mary’s will host St George’s in a repeat of last year’s final.
In the other tie, Ramsey will meet Peel.
The semi-final draw was made live on Manx Radio on Saturday evening.
Paddy Power FA Cup semi-finals
St Mary’s v St George’s
Ramsey v Peel
FC IoM boss says levels need lifting for Charnock Richard visit
Ravens suffered heaviest home defeat of campaign last time out
Hockey: Two league titles to be decided on final day
Men's Prem and Men's Div 1 going down to the wire this weekend
Rugby: Douglas and Vagabonds to conclude league campaigns this weekend
Both facing tough opposition in final 2024/25 league season outings
Football: 2025 Hospital Cup to begin this weekend
Prelim rounds of that and Junior Cup to take place (Fixtures: 5-6 Apr)
Cycling: Ruby Oakes to make Women's WorldTour debut?
18-year-old in provisional startlist for Tour of Flanders this weekend