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Roads around the Billown Circuit in the south of the Island will close at 6.05pm today (Friday), at the start of the Blackfords Pre-TT Classic meeting.
The first practice session will get under way at 6.15pm and the roads will reopen no later than 9.35pm.
There will be a further practice session tomorrow afternoon, with one race at 4pm.
The rest of the race programme takes place throughout the day on Monday.
Football: Braddan and Rushen United progress in Ecap FA Cup
Poor weather once again heavily disrupts local fixtures
Rugby: Ramsey take early lead in Counties 3 ADM minor conference
Celts win 'old firm' clash in Manx Cup
Hockey: IoM Ladies A march on in EH Championships
Bacchas B keep up perfect run in Men's Division One
FC Isle of Man's trip to Barnoldswick Town postponed
Travel disruption and player welfare behind decision
Hockey: Bacchas Men's B looking to keep up flawless league form
Two national teams in EH Championship action in this weekend's fixtures