Ramsey were unable to build on last week’s performance as they went down 26-12 at Moore in South Lancashire/Cheshire Division Two.
Moore led 19-0 at half-time after Ramsey had a poor start.
The Manx side came back in the second half with tries from Glyn Hooson-Owen and John Watling, plus a conversion from Fintan Cummins.
A last minute converted try from Moore denied Ramsey a losing bonus point.
Commonwealth Games could have 'very different' feel in 2026
Manx team still facing some unknowns and challenges ahead of Glasgow
Shooting: Corlett claims high gun in winter series first round
Bellhouse and Doyle also among winners at Meary Veg
Cycling: Lizzie Holden taking time to adjust to retirement
Manx pro rider brought career to an end last month
Powerlifting: Isle of Man to host Home Nations in 2026
It'll be the first time it's taken place on the Island
Snooker: Blinders take victory to go top
Gardner equals highest break of the season so far