Football - Corinthians face a major test of their Railway Cup credentials.
They face a trip to The Bowl to face rivals St. Mary's in the Premier League knowing they must win to have a realistic chance of claiming a semi-final berth.
Leaders Laxey go to Gymns, Champions St. George's are at bottom-of-the-table Marown and St. John's host Old Boys.
Old firm rivals Peel and Rushen clash at Douglas Road and Castletown entertain Union Mills.
In Rugby, Douglas are away at struggling Oldershaw hoping to make it six wins out of six in South Lancashire and Cheshire Division Two.
Vagabonds tackle Oswestry at Ballafletcher and Ramsey face a big test at home to promotion chasing Ormskirk.
Vagas ladies are also in action away to Liverpool Collegiate.
In Hockey, the top two in the Mixed Premier League are looking for fifth straight victories.
Leaders Bacchas "A" play Celts while Champions Valkyrs "A" face their own "B" team in a club derby.
Ravens chasing club record win streak at Pilkington
Hockey: Mixed Premier League title fight goes to final day
Rugby: Southern Nomads aim for Cheshire Bowl final
Football: Premier league top two both on the road
Banned MGP rider 'to get racing licence reinstated'