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The Post Office says normal deliveries and collections would be severely disrupted, if next week's planned walkout by some staff went ahead.
According to a letter sent to business customers, priority would be given to services such as special and early morning deliveries, at the expense of others.
Meanwhile, Communication Workers Union representative Terry Pullinger told Manx Radio there was still time to stop the 24-hour strike planned for a week today (Tuesday), but it would depend on the outcome of talks scheduled for tomorrow and Thursday.
Mr Pullinger also strongly rebuffed Post Office chairman Alan Crowe's claim the CWU had wanted to go on strike all along:
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